Actress Marley Shelton is off to Ann Arbor, Michigan to take on a new Ghostface killer and replace starlet Lake Bell in director Wes Craven’s now-shooting Scream 4. Shelton will play a deputy sheriff who knew Sidney Prescott (Neve Campbell) back in high school.

The sexy 36-year-old blonde knows a thing or two about scary movies.

She has starred in such brutal frighteners as last year’s Milla Jovovich vehicle A Perfect Getaway, Quentin Tarantino and Robert Rodriguez’s Grindhouse mash-up, Rodriguez’s own Sin City, and Warner Bros. 2001 revenge-slasher Valentine.

Scream 4 is written by original franchise scribe Kevin Williamson (“The Vampire Diaries”) and costars Emma Roberts, Hayden Panettiere, Rory Culkin, Adam Brody, Erik Knudsen, Nico Tortorella, and old-schoolers Campbell, Courteney Cox, and David Araquette.

“Gilmore Girl” Lauren Graham had signed on to star in the film as well, but is now rumored to have backed out.

Scream 4 will be in theaters on April 15, 2011.