Demi Moore and Once Upon a Time In Hollywood stunner Margaret Qualley go nude in writer-director Coralie Fargeat’s The Substance, a followup to her feature debut Revenge, a ball-busting thriller included in Clatto’s prestigious list of The 10 Sexiest Horror Films of 2017.

Moore plays an aging starlet fired from her workout show on her 50th birthday. She attempts to regain her youthful beauty with the help from a black market drug that will allow her to live in her present body and in that of her stroke-worthy younger self. The only catch is she has to take turns in each.

Trouble kicks in when Moore’s gilfy body grows jealous of her banging younger bod, which is has gotten her job back and is getting lots of attention.

Qualley, daughter of Andie MacDowell, best known for starring in HBO’s rapture drama “The Leftovers” and Quentin Tarantino’s Once Upon a Time In Hollywood as a hot Manson family cult member, plays the seasoned starlet’s younger body.

Moore and Qualley do full-frontal nudity throughout the film. In an interview with The LA Times, Moore said about the nudity, “I did admire how round Margaret’s ass was.”

The Substance arrives in theaters on Sept. 20.