Warner Bros. has released the first official trailer for director Vincenzo Natali’s (Cube) long-delayed sci-fi morality tale Splice, starring Adrien Brody (Predators) and Sarah Polley (Dawn of the Dead) as ethically-compromised geneticists who successfully splice human and animal DNA to create a hybrid female named Dren.

Take a look:

I don’t know a lot about science, but I think things would have gone better for everyone in this movie if Brody and Polley’s characters had simply followed the John Hughes formula of Barbie doll + game of Life + bra on head = Kelly LeBrock. Just saying.

Splice arrives in theaters on June 4. To see images and read an interview with director Vincenzo Natali, click here.